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:DIf the pill is bright pink, the pill is chloroquine phosphate 500 mg. Chloroquine may be used in addition to nonsteroidal anti-inflammatory agents {05}. Chloroquine with daily proguanil may be more effective than chloroquine alone {35}. However, chloroquine should be used in areas with chloroquine-sensitive P. Epinephrine has been shown to decrease the myocardial depressant and vasodilatory effects of chloroquine {19} {20}. The dose of activated charcoal should be 5 to 10 times the estimated dose of chloroquine ingested {01} {02} {06} {18}. However, risk-benefit must be considered since chloroquine, given in therapeutic doses, has been shown to cause central nervous system (CNS) damage, including ototoxicity (auditory and vestibular); congenital deafness; retinal hemorrhages; and abnormal retinal pigmentation {01} {02} {06}. Although problems in humans have not been documented, risk-benefit must be considered since infants and children are especially sensitive to the effects of chloroquine {02}. Chloroquine, given in weekly chemoprophylactic doses, has not been shown to cause adverse effects in the fetus. 4 mg (base) per kg per day of chloroquine {03}. , abortion and death) than prophylactic administration of chloroquine {01} {02} {06}. In acute attacks of malaria, chloroquine interrupts erythrocytic schizogony of the parasite. When chloroquine is used for the short-term treatment of malaria or other parasitic diseases, side/adverse effects are usually mild and reversible {01} {02} {06}. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. Children who cannot take mefloquine or doxycycline can be given chloroquine for prophylaxis in chloroquine-sensitive areas {31} {41}. Weekly mefloquine is recommended for most travelers to areas with chloroquine-resistant Plasmodium falciparum {36}. Fatalities have been reported following the ingestion of as little as 300 mg of chloroquine base in a 12-month-old child {21}. In suppressive treatment, chloroquine inhibits the erythrocytic stage of development of plasmodia {01} {02} {06} {29}. In addition, resistance to both chloroquine and the sulfadoxine and pyrimethamine combination is widespread in Thailand, Myanmar, Cambodia, and the Amazon basin area of South America; resistance also has been reported sporadically in sub-Saharan Africa {35}. Doses of chloroquine phosphate as small as 300 mg in children, and 2. Chloroquine crosses the placenta and is distributed into *** milk {02} {09} {15}. Chloroquine is excreted very slowly and may persist in urine for months or years after medication is discontinued {09} {15}. The combination of chloroquine and proguanil for sub-Saharan Africa has lower efficacy than other regimens {41}. Doxycycline is also often used for chloroquine-sensitive strains in patients who cannot take chloroquine {109}. So visit the website and type chloroquine in the top left search box.
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