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Each tablet contains the labeled amount of bupropion hydrochloride and the inactive ingredients: ethylcellulose aqueous dispersion (NF), glyceryl behenate, methacrylic acid copolymer dispersion (NF), polyvinyl alcohol, polyethylene glycol, povidone, silicon dioxide, and triethyl citrate. When symptoms were reported, most were during treatment with bupropion, but some were following discontinuation of treatment with bupropion. Serious neuropsychiatric events, including but not limited to depression, suicidal ideation, suicide attempt, and completed suicide have been reported in patients taking bupropion for smoking cessation. Conversely, bupropion may antagonize the central pharmacologic effects of sedatives. You may have a higher risk of seizures if you use certain medications together with bupropion. However, some of these symptoms have occurred in patients taking bupropion who continued to smoke. Anyone considering the use of bupropion or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Bupropion has been demonstrated to increase the likelihood of abstinence from smoking for as long as 6 months compared to treatment with placebo. Do not take an MAO inhibitor within 14 days of taking bupropion. Bupropion passes into *** milk and could be harmful to a nursing baby. The patient should stop taking bupropion and contact a healthcare provider immediately if any neuropsychiatric behavior that is not typical for the patient is observed, or if the patient develops suicidal ideation or suicidal behavior. Do not take bupropion without telling your doctor if you are ***-feeding a baby. Bupropion can cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication. Bupropion hydrochloride powder is white, crystalline, and highly soluble in water. The use of bupropion is contraindicated in patients undergoing abrupt discontinuation of sedatives. After 3 weeks though, I had a severe allergic reation to the Wellbutrin (bupropion) and had to go to the ER twice in a week. It is very important that you receive only one prescription for bupropion at a time. In many postmarketing cases, resolution of symptoms after discontinuation of bupropion was reported, although in some cases the symptoms persisted; therefore, ongoing monitoring and supportive care should be provided until symptoms resolve. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving bupropion. Alcohol may increase your risk of a seizure while you are taking bupropion. If you are already taking medicine for mental depression or to help you stop smoking, discuss this with your doctor before taking bupropion. Bupropion can cause agitation, anxiety, and insomnia and has been shown to decrease the sedative effect of diazepam in healthy volunteers given single doses of the drugs. You should not take bupropion if you have seizures, an eating disorder, if you are using a second form of bupropion, or if you have suddenly stopped using alcohol or sedatives. The amount of bupropion you take may have to be adjusted to meet the needs of your condition and to help avoid unwanted effects. Before taking bupropion, tell your doctor if you are pregnant or plan to become pregnant during treatment. MANAGEMENT: Although sedatives may be prescribed to treat agitation, anxiety, and insomnia associated with bupropion use, patients should be alerted to the possibility of an increased risk of seizures during excessive exposure to these drugs. These symptoms, as well as worsening of pre-existing psychiatric illness and completed suicide have been reported in some patients attempting to quit smoking while taking bupropion in the postmarketing experience. You will probably need to keep taking bupropion for several months to help prevent the return of your depression.
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